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Peptides with fewer residues are more susceptible to rapid enzymatic degradation, leading to shorter systemic exposure. Fosgerau & Hoffmann, Drug Discovery Today Half-Life Each peptide has a defined biological half-life the time it takes for half of the substance to be eliminated from the bloodstream

It noted that oral and intra-articular peptides showed distinct advantages in soft tissue regeneration, with intra-articular routes providing localized effects and oral routes offering systemic benefits

The branchial arches and HGF are growth-promoting and chemoattractant for cranial motor axons

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